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Year : 2012  |  Volume : 1  |  Issue : 2  |  Page : 59-63

Comparison of wound healing activity of Jethimadh with Triphala in rats

1 Department of Pharmacology, RD Gardi Medical College, Ujjain, India
2 Department of Pharmacology, Dr D Y Patil Medical College, Pune, India
3 Department of Pharmacology, NRS Medical College, Kolkata, India
4 Department of Ophthalmology, RD Gardi Medical College, Ujjain, India

Correspondence Address:
Arijit Ghosh
Department of Pharmacology, NRS Medical College, Kolkata
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2278-344X.101665

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Context: Management of wounds is frequently encountered with different problems. Drug resistance and toxicity have hindered the development of synthetic antimicrobial agents with wound healing activity. Many plants with multi-potent pharmacological activities may offer better treatment options. Triphala (dried fruits of Terminalia chebula, Terminalia bellirica, and Phyllanthus emblica) formulations have shown healing activity on wounds. Aims: Aim was to compare the wound healing activity of jethimadh with triphala in rats. Materials and Methods: An ointment was prepared by mixing Jethimadh (Glycyrrhizae glabra Linn) powder in ghee obtained from cow's milk.Triphala ointment was prepared by mixing triphala powder in sesame oil. Both jethimadh and triphala were evaluated for healing activity on rat model of incised and excised wounds. Parameters evaluated for assessment of efficacy of the formulations are tensile strength, level of hydroxyproline, and wound contraction. Results: Efficacy was significant (P < 0.001) with both jethimadh and triphala groups compared with control. Efficacy of Jethimadh is significantly higher compared with triphala in incision wound model, but no statistically significant difference was observed between these two groups in excision wound model. Conclusion: The data suggest that healing activity of jethimadh with respect to triphala is significantly higher on rat model of incised wound and is comparable on rat model of excised wound.

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