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Year : 2012  |  Volume : 1  |  Issue : 3  |  Page : 158-165

Clinical and epidemiological features among hospitalized patients of pandemic influenza A (H1N1) in Saurashtra region, India: A two wave comparison

1 Department of Community Medicine, M. P. Shah Medical College, Jamnagar, India
2 Department of Community Medicine, P. D. U. Medical College, Rajkot, Jamnagar, India
3 Department of Microbiology, M. P. Shah Medical College, Jamnagar, India

Correspondence Address:
Rajesh K Chudasama
Vandana Embroidery, Mato Shree Complex, Sardar Nagar Main Road, Rajkot, Gujarat
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2278-344X.105079

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Objective: To study and compare clinical and epidemiological characteristics of patients who were hospitalized with influenza A (H1N1) infection for two waves in Saurashtra region. Materials and Methods: Total 274 patients admitted during the first wave from September 2009 to March 2010 and 237 during the second wave from June 2010 to February 2011 with 2009 influenza A (H1N1) virus were admitted in different hospitals in Rajkot city. Real-time reverse-transcriptase-polymerase-chain-reaction (RRRT-PCR) testing was used to confirm infection; the clinical and epidemiological features of the disease were closely monitored. Results: The median age of positive cases reported was 27 years in the first wave and 29 years in the second wave, respectively. The median duration of diagnosis of infection was reported five days after onset of illness in both the waves. Majority of patients were reported with cough and fever. Total 160 patients were reported with at least one underlying condition. Hypertension and diabetes mellitus either alone or together was mainly reported as the underlying condition during both season, followed by chronic pulmonary diseases and pregnancy. More number of pregnant women were reported with a range of 5 to 9 months of amenorrhea during first wave (5.5%) compare to second wave (3.0%). Conclusion: We have demonstrated that during two waves, infection-related illness affects both children including infants and adults with survival of 77.2% patients in second wave. Pregnancy was found as a significant (P < 0.05) risk factor for severe disease. Significant number of patients with severe influenza A (H1N1) received antiviral treatment within two days of onset of illness.

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