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ORIGINAL ARTICLE
Year : 2018  |  Volume : 7  |  Issue : 2  |  Page : 89-97

Pharmaceutical standardization and preliminary quality control parameters of Shirishavaleha prepared from two different liquid media


1 Department of Rasashastra and Bhaishajya Kalpana Including Drug Research, Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar, Gujarat, India
2 Department of Rasashastra and Bhaishajya Kalpana, All India Institute of Ayurveda, New Delhi, India

Correspondence Address:
Dr. Harmeet B Kaur
Department of Rasashastra and Bhaishajya Kalpana Including Drug Research, Institute for Post Graduate Teaching and Research In Ayurveda, Gujarat Ayurved University, Jamnagar - 361 008, Gujarat
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijhas.IJHAS_6_1

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CONTEXT: The different dosage forms of Ayurveda are mostly prepared in the presence of Jala (water) as Drava dravya (extracting medium). Transfer of the medicinal properties of any Dravya (drug) is done on the virtue of Drava dravya (liquid medium). Screening through the classics reveal that seers used Drava such as Kshira (cow's milk), Gomutra (cow's urine) and Kanji (sour gruel) in preparing different formulations based on the necessity. These media are either used to get more extraction from the raw material or according to suitability and hence to increase the efficacy of the finished formulation. However, information on comparative profiles of a formulation prepared in the presence of different media is not available till date. AIM: Considering this, it is aimed to develop standard manufacturing procedure and possible analytical profiles of Shirishavaleha prepared from Kanji and water as media. MATERIALS AND METHODS: The formulation was prepared in the presence of water and Kanji with the usage of Twak (bark) of Shirisha (Albizia lebbeck Benth.) in eight batches. The quality control parameters such as determination of pH, moisture, total ash, acid-insoluble ash value, alcohol-soluble extractive value, water-soluble extractive value, total fat, total solid content, total sugar estimation, total saponin, total alkaloids, total tannin estimation, microbial limit test and determination of heavy metals (Cd, Pb, Hg, and As) to develop preliminary analytical profiles and qualitative test for various functional groups and high-performance thin layer chromatography profile were also carried out by following the standard guidelines. RESULTS: No significant differences were found in pharmaceutical and analytical aspects of both the samples of Shirishavaleha. CONCLUSION: The current methods of preparation can be considered as standard in further studies. The absence of microbial contamination and heavy metals reflects the quality and safety aspects of both the formulations.


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