CASE REPORT |
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Year : 2018 | Volume
: 7
| Issue : 4 | Page : 263-265 |
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Disulfiram-induced hyperpigmentation
MC Gupta1, Kartik Nayak1, Savita Verma1, Siddharth Arya2
1 Department of Pharmacology, PGIMS, Rohtak, Haryana, India 2 Department of Psychiatry, PGIMS, Rohtak, Haryana, India
Correspondence Address:
Dr. Kartik Nayak Department of Pharmacology, PGIMS, Rohtak, Haryana India
Source of Support: None, Conflict of Interest: None | Check |
DOI: 10.4103/ijhas.IJHAS_44_18
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Abnormal pigmentation of skin is a less morbid condition but can be more distressing to the patient and a major cause of psychological distress. Disulfiram is the first-line drug for the treatment of alcohol dependence. It inhibits acetaldehyde dehydrogenase resulting in accumulation of aldehyde component of ethanol metabolism leading to unpleasant effects. Disulfiram-induced dermatological disorders correspond to an intermediate rate of adverse reactions, and occurrence of hyperpigmentation is a very rare phenomenon. In this submission, we report a case of disulfiram-induced hyperpigmentation in a patient being treated for alcohol dependence.
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