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SHORT COMMUNICATION
Year : 2012  |  Volume : 1  |  Issue : 2  |  Page : 129-132

A RP-HPLC method for simultaneous estimation of ondansetron and ranitidine in pharmaceutical formulation


1 Department of Pharmaceutical Analysis, J. S. S. College of Pharmacy, (Off Campus College of JSS University, Mysore), Karnataka, India
2 Vice-Chancellor, J. S. S. University, Mysore, Karnataka, India

Correspondence Address:
S N Meyyanathan
Department of Pharmaceutical Analysis, J. S. S. College of Pharmacy, (Off Campus College of JSS University, Mysore), Ootacamund-643 001, Tamil Nadu
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2278-344X.101723

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A simple, selective, rapid, precise and economical reverse phase HPLC method has been developed for the simultaneous estimation of ondansetron and ranitidine from pharmaceutical dosage forms. The method was carried out using a Phenomenex column C 18 (250 mm × 4.6 mm, i.d 5 μ) with a mobile phase consisting of 50 mM potassium dihydrogen orthophosphate: acetonitrile (pH 6, ratio 60:40 v/v) at a flow rate of 0.8 ml/min. Detection was carried out at 222 nm. Pantoprazole was used as an internal standard. The retention time of ondansetron, ranitidine, and pantoprazole were found to be 6.4, 3.0 and 11.0 min, respectively. The developed method was validated in terms of its accuracy, precision, linearity, limit of detection, limit of quantitation, and solution stability. The proposed method can be used for the estimation of these drugs in a combined dosage form.


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