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| LETTER TO EDITOR |
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| Year : 2012 | Volume
: 1
| Issue : 3 | Page : 208-209 |
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Acinetobacter infection in the Neonatal Intensive Care Unit in a tertiary care hospital in India: Risk factors, susceptibility profiles
Kalidas Rit1, Bipasa Chakraborty1, Parthasarathi Chakrabarty1, Rajdeep Saha2
1 Department of Microbiology, Institute of Post-Graduate Medical Education and Research, Kolkata, India
2 Department of Microbiology, National Medical College, Kolkata, India
| Date of Web Publication | 26-Dec-2012 |
Correspondence Address:
Kalidas Rit
70B T.C. Mukherjee street, PO: Rishra, Hooghly - 712248
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/2278-344X.105092
How to cite this article:
Rit K, Chakraborty B, Chakrabarty P, Saha R. Acinetobacter infection in the Neonatal Intensive Care Unit in a tertiary care hospital in India: Risk factors, susceptibility profiles. Int J Health Allied Sci 2012;1:208-9 |
How to cite this URL:
Rit K, Chakraborty B, Chakrabarty P, Saha R. Acinetobacter infection in the Neonatal Intensive Care Unit in a tertiary care hospital in India: Risk factors, susceptibility profiles. Int J Health Allied Sci [serial online] 2012 [cited 2023 Mar 30];1:208-9. Available from: https://www.ijhas.in/text.asp?2012/1/3/208/105092 |
Sir,
Septicemia is a significant cause of morbidity and mortality in the newborns particularly in the developing countries. According to National Neonatal Perinatal Database (2002-2003) in India, the incidence of neonatal septicemia is 30/1000 live births. [1] Along with other organisms like Escherichia More Details coli, Klebsiella spp, Staphylococcus aureus, and Pseudomonas spp, Acinetobacter spp has also emerged as a very important nosocomial pathogen, especially in neonatal critical care unit, and is a matter of concern with regard to prolonged hospital stay, increasing the economic burden and worsening of clinical outcome. [2] A prospective case control study of blood stream infection was conducted to know the infection rate, susceptibility pattern of different Acinetobacter species, and the risk factors associated with mortality because of Acinetobacter infection.
From January 2011 to February 2012, 550 consecutive blood samples of suspected neonatal septicemia were collected and cultured for the isolation of aerobic bacteria. The organisms were identified by conventional methods and antimicrobial testing was done according to Kirby-Bauer's disc diffusion method. [3] One hundred and ninety collected blood samples were positive in culture and Acinetobacterspp were isolated from 30 (15.78%) of which 18 were A. baumanii and 12 were A. lwoffii. Eleven were term babies and 19 were preterm. Babies with institutional delivery had higher isolation of Acinetobacter spp. (24/30). Community acquired infection was 12%. Sixty seven percent patients were male. The isolates of Acinetobacter were mostly resistant to commonly used antibiotic and susceptibility pattern to imipenem (88%), meropenem (89%), amikacin (54%), ciprofloxacin (70%), gentamicin (40%), ceftriaxone (48%), cefuroxime (30%), cefotaxime (38%), colistin (85%) were found in our study. Overall crude mortality rate was 22% with much higher mortality among patients with hospital acquired infection. Based on the logistic regression, the following were statistically significant: birth weight <1400 gm, age <7 day, empirical antibiotic use, prolonged rupture of membrane, mean days of hospital stay for 18 days or more and on mechanical ventilation when compared to control group (P < 0.05).
The incidence of Acinetobacter septicaemia in this study was 15.78%. It was comparable with the finding of the study that was conducted by Arora et al. (12.3%) [4] and Mondal et al. (15.2%). [5] However, the incidence was higher than that reported by Vinod kumar and Neelagund (8.3%). [2]
The infection rate of nosocomial blood stream infection by A. baumanii was considerable and alarming in Neonatal Intensive Care Unit (NICU) and associated with a significant excess length of NICU stay and a significant economic burden. Implementation of infection control policies, careful disinfection of Intensive care equipments and rational use of antibiotic are required to control such infection.
| Acknowledgments | |  |
Prof Prasanta Kumar Maiti, MD, Prof and Head, Institute of Post-Graduate Medical Education and Research. 244 AJC Bose Road. Kolkata-700020.
| References | | |
| 1. | Sankar MJ, Agarwal R, Deorari AK, Paul VK. Sepsis in the newborn. Indian J Pediatr 2008;75:261-6. 
[PUBMED] |
| 2. | Vinodkumar CS, Neelagund YF. Acinetobacter Septicemia in Neonates. Indian J Med Microbiol 2004;22:71.
[PUBMED] |
| 3. | Bauer AW, Kirby WMM, Sherris JC, Turek M. Antibiotic sensitivity testing by a standardized single disk method. Am J Clin Path 1966;45:493-6.
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| 4. | Arora U, Jaitwani J. Acinetobacter spp.- An emerging causative pathogen of neonatal septicaemia in Amritsar. Indian J Med Microbiol 2006;24:81.
[PUBMED]  |
| 5. | Mondal GP, Raghvan M, Vishnu B, Srinivasan S. Neonatal septicaemia among inborn and outborn babies in a referral hospital. Indian J Paediatr 1991;58:529-33.
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