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LETTER TO EDITOR
Year : 2012  |  Volume : 1  |  Issue : 3  |  Page : 208-209

Acinetobacter infection in the Neonatal Intensive Care Unit in a tertiary care hospital in India: Risk factors, susceptibility profiles


1 Department of Microbiology, Institute of Post-Graduate Medical Education and Research, Kolkata, India
2 Department of Microbiology, National Medical College, Kolkata, India

Date of Web Publication26-Dec-2012

Correspondence Address:
Kalidas Rit
70B T.C. Mukherjee street, PO: Rishra, Hooghly - 712248
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2278-344X.105092

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How to cite this article:
Rit K, Chakraborty B, Chakrabarty P, Saha R. Acinetobacter infection in the Neonatal Intensive Care Unit in a tertiary care hospital in India: Risk factors, susceptibility profiles. Int J Health Allied Sci 2012;1:208-9

How to cite this URL:
Rit K, Chakraborty B, Chakrabarty P, Saha R. Acinetobacter infection in the Neonatal Intensive Care Unit in a tertiary care hospital in India: Risk factors, susceptibility profiles. Int J Health Allied Sci [serial online] 2012 [cited 2022 Nov 30];1:208-9. Available from: https://www.ijhas.in/text.asp?2012/1/3/208/105092

Sir,

Septicemia is a significant cause of morbidity and mortality in the newborns particularly in the developing countries. According to National Neonatal Perinatal Database (2002-2003) in India, the incidence of neonatal septicemia is 30/1000 live births. [1] Along with other organisms like  Escherichia More Details coli, Klebsiella spp, Staphylococcus aureus, and Pseudomonas spp, Acinetobacter spp has also emerged as a very important nosocomial pathogen, especially in neonatal critical care unit, and is a matter of concern with regard to prolonged hospital stay, increasing the economic burden and worsening of clinical outcome. [2] A prospective case control study of blood stream infection was conducted to know the infection rate, susceptibility pattern of different Acinetobacter species, and the risk factors associated with mortality because of Acinetobacter infection.

From January 2011 to February 2012, 550 consecutive blood samples of suspected neonatal septicemia were collected and cultured for the isolation of aerobic bacteria. The organisms were identified by conventional methods and antimicrobial testing was done according to Kirby-Bauer's disc diffusion method. [3] One hundred and ninety collected blood samples were positive in culture and Acinetobacterspp were isolated from 30 (15.78%) of which 18 were A. baumanii and 12 were A. lwoffii. Eleven were term babies and 19 were preterm. Babies with institutional delivery had higher isolation of Acinetobacter spp. (24/30). Community acquired infection was 12%. Sixty seven percent patients were male. The isolates of Acinetobacter were mostly resistant to commonly used antibiotic and susceptibility pattern to imipenem (88%), meropenem (89%), amikacin (54%), ciprofloxacin (70%), gentamicin (40%), ceftriaxone (48%), cefuroxime (30%), cefotaxime (38%), colistin (85%) were found in our study. Overall crude mortality rate was 22% with much higher mortality among patients with hospital acquired infection. Based on the logistic regression, the following were statistically significant: birth weight <1400 gm, age <7 day, empirical antibiotic use, prolonged rupture of membrane, mean days of hospital stay for 18 days or more and on mechanical ventilation when compared to control group (P < 0.05).

The incidence of Acinetobacter septicaemia in this study was 15.78%. It was comparable with the finding of the study that was conducted by Arora et al. (12.3%) [4] and Mondal et al. (15.2%). [5] However, the incidence was higher than that reported by Vinod kumar and Neelagund (8.3%). [2]

The infection rate of nosocomial blood stream infection by A. baumanii was considerable and alarming in Neonatal Intensive Care Unit (NICU) and associated with a significant excess length of NICU stay and a significant economic burden. Implementation of infection control policies, careful disinfection of Intensive care equipments and rational use of antibiotic are required to control such infection.


  Acknowledgments Top


Prof Prasanta Kumar Maiti, MD, Prof and Head, Institute of Post-Graduate Medical Education and Research. 244 AJC Bose Road. Kolkata-700020.

 
  References Top

1.Sankar MJ, Agarwal R, Deorari AK, Paul VK. Sepsis in the newborn. Indian J Pediatr 2008;75:261-6.  Back to cited text no. 1
[PUBMED]    
2.Vinodkumar CS, Neelagund YF. Acinetobacter Septicemia in Neonates. Indian J Med Microbiol 2004;22:71.  Back to cited text no. 2
[PUBMED]    
3.Bauer AW, Kirby WMM, Sherris JC, Turek M. Antibiotic sensitivity testing by a standardized single disk method. Am J Clin Path 1966;45:493-6.  Back to cited text no. 3
    
4.Arora U, Jaitwani J. Acinetobacter spp.- An emerging causative pathogen of neonatal septicaemia in Amritsar. Indian J Med Microbiol 2006;24:81.  Back to cited text no. 4
[PUBMED]  Medknow Journal  
5.Mondal GP, Raghvan M, Vishnu B, Srinivasan S. Neonatal septicaemia among inborn and outborn babies in a referral hospital. Indian J Paediatr 1991;58:529-33.  Back to cited text no. 5
    




 

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