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Year : 2013  |  Volume : 2  |  Issue : 2  |  Page : 130-132

Fixed drug eruption due to fixed dose combination: A novel case

Department of Pharmacology, Mahatma Gandhi Institute of Medical Sciences, Sevagram, Wardha, Maharashtra, India

Correspondence Address:
Arup Kumar Misra
Department of Pharmacology, Mahatma Gandhi Institute of Medical Sciences, Sevagram - 442 102, Maharashtra
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2278-344X.115691

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Fixed drug eruption is a well documented drug side effect and accounts for about 5-10% of cutaneous drug reactions. We describe a case of fixed drug eruption on lips and perioral region following consumption of a fixed dose combination in acute gastroenteritis. Fixed dose combination of Ofloxacin and Ornidazole is one of the most commonly used medications for acute gastroenteritis. Fixed drug reaction caused in this case was red, raised macule, which turned into blister and later followed by post-inflammatory hyperpigmentation. Delayed type IV hypersensitivity reaction is most probably the reason for the mechanism of fixed drug reaction.

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