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Year : 2013  |  Volume : 2  |  Issue : 2  |  Page : 81-87

Microwave assisted synthesis, characterization and evaluation for their antimicrobial activities of some novel pyrazole substituted 9-anilino acridine derivatives

Department of Pharmaceutical Chemistry, JSS College of Pharmacy, Ootacamund, Tamil Nadu, India

Correspondence Address:
Rajagopal Kalirajan
Department of Pharmaceutical Chemistry, JSS College of Pharmacy, Ootacamund - 643 001, Tamil Nadu
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2278-344X.115682

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Objective: The paper focuses on the microwave synthesis of a new series of 9-anilinoacridine derivatives 4a-g, 5a-g, and 6a-g. Materials and methods: The compounds were confirmed by physical and analytical data. The synthesized compounds when screened for in vitro anti-microbial activity showed promising activity for many compounds. The in vitro anti-microbial activities of the synthesized compounds were evaluated against some bacteria and fungi strains. Results and Discussions: The results suggested that, the products 4a-g, 5a-g, and 6a-g exhibited good inhibitory effect against most of the tested organisms. Especially, 4b, 5a, 5d, 6b, and 6e were shown to be most effective against Bacillus subtilis, Escherichia coli at the concentration of 25 μg/ml and Candida albicans at the concentration of 50 μg/ml.

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