Home Print this page Email this page
Users Online: 9
Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 


 
 Table of Contents  
CASE REPORT
Year : 2014  |  Volume : 3  |  Issue : 3  |  Page : 187-189

Xanthogranulomatous oophoritis: A case report with review of literature


Department of Pathology, MGM Medical College, Aurangabad, Maharashtra, India

Date of Web Publication13-Aug-2014

Correspondence Address:
Suparna Milind Bindu
Department of Pathology, MGM Medical College, Aurangabad, Maharashtra
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2278-344X.138604

Rights and Permissions
  Abstract 

Xanthogranulomatous inflammation is an uncommon form of chronic inflammation in which the affected organ is destroyed and is replaced by large number of lipid - containing macrophages with an admixture of lymphocytes, plasma cells and multinucleated giant cells. The most commonly affected organs are the kidney and gall bladder, followed by anorectal area, bone, stomach, and testis. The inflammation most often affects the endometrium in the female genital tract, but involvement of the vagina, cervix, fallopian tube, and ovary may also occur. Only a few cases involving the ovary have been reported. We report a case of xanthogranulomatous infection of ovary in a 40-year-old female who presented with abdominal pain and bleeding per vaginum. Her clinical examination, radiological evaluation, surgical findings and gross features were likely to be mistaken for malignancy if xanthogranulomatous inflammation was missed as a differential diagnosis.

Keywords: Histiocytes, oophoritis, xanthogranulomatous


How to cite this article:
Bindu SM, Mahajan MS. Xanthogranulomatous oophoritis: A case report with review of literature. Int J Health Allied Sci 2014;3:187-9

How to cite this URL:
Bindu SM, Mahajan MS. Xanthogranulomatous oophoritis: A case report with review of literature. Int J Health Allied Sci [serial online] 2014 [cited 2021 Mar 8];3:187-9. Available from: https://www.ijhas.in/text.asp?2014/3/3/187/138604


  Introduction Top


The presence of a large number of lipid containing macrophages with an admixture of lymphocytes, plasma cells, and neutrophils is characteristic of xanthogranulomatous inflammation. Multinucleated giant cells may also be present. Xanthogranulomatous inflammation is a form of chronic inflammation that is destructive to the normal tissue of affected organs. [1] Most commonly affected organ is kidney, followed by gall bladder. [2] Other organs in which xanthogranulomatous inflammation has been reported are stomach, anorectal area, bone, urinary bladder, testis, epididymis and female genital tract. Only a few cases of xanthogranulomatous oophoritis have been reported till date. [3],[4],[5]


  Case report Top


A 40-year-old female presented with abdominal pain and bleeding per vaginum since 8 days. On examination, there was a mass in the right pelvic region. Computed tomography scan showed multiloculated septate lesion in the right adenexa, suggestive of mucinous cystadenoma or mucinous carcinoma. Total abdominal hysterectomy with bilateral salpingo-oophorectomy was done. We received a specimen of uterus with one sided  Fallopian tube More Details and ovary, along with a separate tubo-ovarian mass and a piece of omentum. Size of the mass was 7 cm × 5 cm × 5 cm; cut surface was partly solid, with a yellowish tinge and partly cystic [Figure 1]. Histologically, it showed ovarian stroma almost completely replaced with dense inflammatory cell infiltrate consisting of large number of foamy histiocytes, accompanied by lymphocytes and plasma cells and plenty of necrosis. There was no evidence of malignancy in the sections studied from the tubo-ovarian mass [Figure 2].
Figure 1: Gross appearance showing partly cystic and partly solid yellowish mass

Click here to view
Figure 2: Microscopic picture showing replacement of ovarian stroma by foamy histiocytes

Click here to view



  Discussion Top


Xanthogranulomatous oophoritis is a rare form of chronic oophoritis. [6] The inflammation most often affects the endometrium in the female genital tract, but involvement of the vagina, cervix, fallopian tube and ovary may also occur. [7] Only a few cases of xanthogranulomatous oophoritis have been reported from India. Only 14 cases of xanthogranulomatous inflammation involving the ovary have been reported until date. Kunakemakorn was the first to describe xanthogranulomatous inflammation of serosa of the uterus, left fallopian tube and ovary in his report of inflammatory pseudotumour in the pelvis in 1976. [8] The exact pathogenesis of xanthogranulomatous inflammation is still unclear. Proposed etiologic factors include chronic bacterial infections, ineffective antibiotic therapy, ineffective clearance of bacteria by phagocytes, abnormality in macrophage, Gram-negative or anerobic bacteria as in genitourinary tract infections, foreign material such as retained suture material [9] and long standing pelvic inflammatory disease. [10],[11] Bacteria like Bacteroides fragilis,  Escherichia More Details coli, Staphylococcus aureus,  Salmonella More Details typhi can be considered in the pathogenesis of xanthogranulomatous oophoritis. Punia et al. have reported a case of xanthogranulomatous oophoritis and salpingitis as a late sequelae of inadequately treated staphylococcal pelvic inflammatory disease. [12],[13] Shukla et al. have reported a case of xanthogranulomatous oophoritis associated with primary infertility and endometriosis. [14] Premature ovarian failure as a rare sequelae of xanthogranulomatous inflammation has also been reported. [15] Cases of xanthogranulomatous inflammation of ovary with ovarian hemangioma, [16] secondary to diverticulitis, [17] as an unusual cause of tubo-ovarian abscess, [18] association with endometriosis and uterine leiomyoma, [19],[20] association with diabetes mellitis, [21] secondary to talcum powder, [22] presenting as an unusual complication of typhoid [23] and following uterine artery embolization [24] have been reported.

The average age of patients with affected ovaries is 31 years [25],[26] and the youngest case reported was of 18 years. The clinical presentations include pain in abdomen, fever, abdominal mass, menorrhagia, anemia, and anorexia. Gynecological examination reveals adenexal mass with tenderness. Laboratory tests show elevated erythrocyte sedimentation rate and raised white blood cell count. Radiological findings of xanthogranulomatous oophoritis may simulate a malignant ovarian neoplasm. Grossly, the involved ovary is replaced by a solid, yellow, well-circumscribed, lobulated mass, sometimes involving adjacent organs, thus simulating malignancy. This mass can be occasionally cystic due to liquefactive necrosis. Histologically, foamy histiocytes (xanthoma cells), and chronic inflammatory cells are consistently observed. Xanthoma cells are histiocytes with abundant lipid laden cytoplasm having vacuolated appearance. It is aggregates of such foam cells, which are responsible for the yellow color observed on gross examination. [27] The emergence of foam cells may be attributed to the following factors:

  1. Inefficient or inappropriate antibiotics applied in the early phase of infection that resulted in ineffective control of bacterial multiplication.
  2. Presence of a lipid metabolic disorder that induces hyperlipidemia and the foam cells are formed when the lipid deposited is phagocytosed by phagocytes.
  3. The application of intrauterine contraceptive devices or drugs, [28] involvement of adjacent organs and pelvic peritoneum results in adhesions, hence arousing the suspicion of malignancy.


The present case is consistent with the clinical findings of other reported cases of xanthogranulomatous oophoritis. We received a specimen of abdominal hysterectomy with bilateral ovaries and tubo-ovarian mass with a piece of omentum, which suggests strong clinical suspicion of malignancy. Gross and histologic findings were also characteristic. The treatment of choice for xanthogranulomatous oophoritis is oophorectomy. Though antibiotic therapy has been attempted, it has been of little use in reducing the size of the mass. Since this entity is usually associated with pelvic inflammatory disease, endometriosis, intrauterine death, these patients should be followed-up closely for early diagnosis. Awareness of this entity is vital in order to prevent misdiagnosis of malignancy and avoid radical surgery.


  Conclusion Top


Xanthogranulomatous inflammation of the ovary is an uncommon entity. The clinical and radiological features of this entity may mimic an ovarian neoplasm, so it must be considered in the differential diagnosis of ovarian tumors. Second, most of the patients using intrauterine contraceptive devices and those of pelvic inflammatory disease and endometriosis need close follow-up as they are prone for xanthogranulomatous oophoritis; so that they are diagnosed early and radical surgery is avoided.


  Acknowledgment Top


The authors are thankful to the authorities of MGM Medical College, Aurangabad, Maharashtra, India for providing necessary facilities for the concerned case study.

 
  References Top

1.Gray Y, Libbey NP. Xanthogranulomatous salpingitis and oophoritis: a case report and review of the literature. Arch Pathol Lab Med 2001;125:260-3.  Back to cited text no. 1
    
2.Shilpa D, Sulhyan K, Sachin B, Gosavi A, Ramteerthkar N. Xanthogranulomatous oophoritis: Case report. Indian J Basic Appl Med Res 2013;7:745-9.  Back to cited text no. 2
    
3.Karigoudar MH, Kushtagi AV, Karigoudar RM, Sirasagi A. Xanthogranulomatous oophoritis - A rare inflammatory lesion. J Krishna Inst Med Sci Univ 2013;2:111-5.  Back to cited text no. 3
    
4.Kumar UM, Potekar RM, Yelikar BR, Pande P. Xanthogranulomatous oophoritis-masquerading as ovarian neoplasm. Asian J Pharm Health Sci 2012;2:308-9.  Back to cited text no. 4
    
5.Koh MW, Kim JH, Kim MJ. A case of xanthogranulomatous oophoritis developed in a virgin. Korean J Obstet Gynecol 2007;50:1048-52.  Back to cited text no. 5
    
6.Raj JA, Jagadeesha M, Naveen S, Ramachandra U. Xanthogranulomatous oophoritis: pathologic findings with clinical correlation. J Indian Med Assoc 2012;110:653-4.  Back to cited text no. 6
    
7.Davis M, Whitley ME, Haque AK, Fenoglio-Preiser C, Waterman R. Xanthogranulomatous abscess of a mullerian duct remnant. A rare lesion of the rectum and anus. Dis Colon Rectum 1986;29:755-9.  Back to cited text no. 7
[PUBMED]    
8.Kallol M, Bafna UD, Mukherjee G, Uma Devi K, Gurubasavangouda, Rathod PS. A rare xanthogranulomatous oophoritis presenting as ovarian cancer. Online J Health Allied Sci 2012;11:1-2.  Back to cited text no. 8
    
9.Tai S, Liang C. A case of genitourinary xanthogranulomatous inflammation. Gynecol Obstet 2013;160:1-3.  Back to cited text no. 9
    
10.Howey JM, Mahe E, Radhi J. Xanthogranulomatous salpingitis associated with a large uterine leiomyoma. Case Rep Med 2010;2010:970805.  Back to cited text no. 10
    
11.Pace EH, Voet RL, Melancon JT. Xanthogranulomatous oophoritis: an inflammatory pseudotumor of the ovary. Int J Gynecol Pathol 1984;3:398-402.  Back to cited text no. 11
[PUBMED]    
12.Punia RS, Aggarwal R, Amanjit, Mohan H. Xanthogranulomatous oophoritis and salpingitis: late sequelae of inadequately treated staphylococcal PID. Indian J Pathol Microbiol 2003;46:80-1.  Back to cited text no. 12
    
13.Chechia A, Bahri N, Felah R, Khaireddine A, Sakouhi M, Zakhama A. Tubo-ovarian xanthogranulomatous inflammation. Report of a case. Tunis Med 1999;77:593-6.  Back to cited text no. 13
    
14.Shukla S, Pujani M, Singh SK, Pujani M. Xanthogranulomatous oophoritis associated with primary infertility and endometriosis. Indian J Pathol Microbiol 2010;53:197-8.  Back to cited text no. 14
[PUBMED]  Medknow Journal  
15.Singh N, Dadhwal V, Sharma KA, Mittal S. Xanthogranulomatous inflammation: a rare cause of premature ovarian failure. Arch Gynecol Obstet 2009;279:729-31.  Back to cited text no. 15
    
16.Shashikala K, Sharmila PS, Sushma TA, Francis P. Ovarian haemangioma with synchronous xanthogranulomatous inflammation - A rare pathological finding. Int J Health Sci Res 2013;5:116-9.  Back to cited text no. 16
    
17.Altanis S, Raweily E, Katesmark M. Xanthogranulomatous endometritis and oophoritis secondary to diverticulitis. A rare cause of postmenopausal bleeding. J Obstet Gynaecol 2007;27:746-7.  Back to cited text no. 17
    
18.Kim SH, Kim SH, Yang DM, Kim KA. Unusual causes of tubo-ovarian abscess: CT and MR imaging findings. Radiographics 2004;24:1575-89.  Back to cited text no. 18
[PUBMED]    
19.Abeysundara PK, Padumadasa GS, Tissera WG, Wijesinghe PS. Xanthogranulomatous salpingitis and oophoritis associated with endometriosis and uterine leiomyoma presenting as intestinal obstruction. J Obstet Gynaecol Res 2012;38:1115-7.  Back to cited text no. 19
    
20.Yener N, Ilter E, Midi A. Xanthogranulomatous salpingitis as a rare pathologic aspect of chronic active pelvic inflammatory disease. Indian J Pathol Microbiol 2011;54:141-3.  Back to cited text no. 20
[PUBMED]  Medknow Journal  
21.Chou SC, Wang JS, Tseng HH. Malacoplakia of the ovary, fallopian tube and uterus: a case associated with diabetes mellitus. Pathol Int 2002;52:789-93.  Back to cited text no. 21
    
22.Chouairy CJ, Hajal EA, Nehme YA. Xanthogranulomatous oophoritis secondary to talcum powder. Case report and review of the literature. J Med Liban 2012;60:169-72.  Back to cited text no. 22
    
23.Singh UR, Revathi G, Gita R. Xanthogranulomatous oophoritis: An unusual complication of typhoid. J Obstet Gynaecol (Tokyo 1995) 1995;21:433-6.  Back to cited text no. 23
    
24.Singh N, Tripathi R, Mala YM, Arora S. Xanthomatous oophoritis following uterine artery embolisation: Successful conservative surgical management with favourable outcome. BMJ Case Rep 2013;2013:pii: bcr2013010184.  Back to cited text no. 24
    
25.Jung SE, Lee JM, Lee KY, Han KT, Hahn ST. Xanthogranulomatous oophoritis: MR imaging findings with pathologic correlation. AJR Am J Roentgenol 2002;178:749-51.  Back to cited text no. 25
    
26.Kaur S, Bodal VK, Bal MS, Bhagat R, Mohi MK, Kaur J. Oophoritis with xanthogranulomatous change - A case report. Res Rev J Med Health Sci 2013;2:8-9.  Back to cited text no. 26
    
27.Naik M, Madiwale C, Vaideeswar P. Xanthogranulomatous oophoritis - A case report. Indian J Pathol Microbiol 1999;42:89-91.  Back to cited text no. 27
[PUBMED]  Medknow Journal  
28.Zhang XS, Dong HY, Zhang LL, Desouki MM, Zhao C. Xanthogranulomatous inflammation of the female genital tract: report of three cases. J Cancer 2012;3:100-6.  Back to cited text no. 28
    


    Figures

  [Figure 1], [Figure 2]



 

Top
 
 
  Search
 
Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
Access Statistics
Email Alert *
Add to My List *
* Registration required (free)

 
  In this article
Abstract
Introduction
Case report
Discussion
Conclusion
Acknowledgment
References
Article Figures

 Article Access Statistics
    Viewed4563    
    Printed41    
    Emailed0    
    PDF Downloaded263    
    Comments [Add]    

Recommend this journal