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ORIGINAL ARTICLE
Year : 2016  |  Volume : 5  |  Issue : 1  |  Page : 9-14

Anti-diabetic activity of Shilajatvadi Lauha, an Ayurvedic traditional herbo-mineral formulation


1 Department of Rasa Shastra and Bhaishajya Kalpana Including Drug Research, Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar, Gujarat, India
2 Department of Rasa Shastra, Faculty of Ayurveda, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India
3 Department of Pharmaceutics, Neuropharmacology Research Laboratory, n Institute of Technology, Banaras Hindu University, Varanasi, Uttar Pradesh, India

Correspondence Address:
Thakur Rakesh Singh
Department of Rasa Shastra and Bhaishajya Kalpana Including Drug Research, Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar - 361008, Gujarat
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2278-344X.173889

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Context: Shilajatvadi Lauha (SL) is used in Ayurveda as Indian traditional medicine for treating diabetes mellitus. Aims: To explore the anti-diabetic potential of SL in nicotinamide-streptozotocin induced diabetic rats. Materials and Methods: SL (10, 30, and 100 mg/kg) and glibenclamide (10 mg/kg) were orally administered once daily to diabetic rats for 14 days. Blood glucose, plasma insulin, total cholesterol (TC), triglycerides (TGs), low-density lipoprotein-cholesterol (LDL-C), high-density lipoprotein-cholesterol (HDL-C), and very LDL-C (VLDL-C) were examined. Results: SL significantly lowered the blood glucose without any hypoglycemic effect on their control counterparts, which was comparable to that of the standard anti-diabetic drug, glibenclamide. SL also showed reduction in the levels of TC, TGs, LDL-C, VLDL-C, but it increases the levels of plasma insulin and HDL-C in diabetic rats. Conclusions: SL possesses anti-diabetic and anti-hyperlipidemic activities in Type 2DM rats, which seems to scientifically validate its traditional uses and might be a promising drug in the therapy of diabetes mellitus and its hyperlipidemic complications.


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