RT - Journal TY - JOUR A1 - Tomar, Neha A1 - Tomar, Mohit A1 - Gulati, Neha A1 - Nagaich, Upendra T1 - pHEMA hydrogels: Devices for ocular drug delivery YR - 2012/10/1 JF - International Journal of Health & Allied Sciences JO - Int J Health Allied Sci SP - 224 OP - 230 VO - 1 IS - 4 UL - https://www.ijhas.in/article.asp?issn=2278-344X;year=2012;volume=1;issue=4;spage=224;epage=230;aulast=Tomar;t=5 DO - 10.4103/2278-344X.107844 N2 - Drug delivery to eye has become a demanding task because of various constraints of eye i.e., physiological and anatomical, which results in improper therapeutic concentration at the site of action. Due to this problem, frequent dosing was recommended causing patient incompliance and adding to the cost of therapy. To overcome these barriers, researchers have discovered novel ocular delivery systems like hydrogels, ocuserts, colloidal carriers, etc. However, every delivery system has its own advantages and disadvantages. Hydrogels are presently utilized as delivery system for actives because of their comparable physical properties to that of living tissue. A plethora of biodegradable polymers are used for hydrogel formulations like polyanhydrides, poly (orthoesters), polyesters and poly (2-hydroxyethyl methacrylate) (pHEMA), chitosan and sodium alginate out of which pHEMA hydrogels are becoming popular from a therapeutic point of view for the ocular drug delivery. The present paper broadly describes the recent advances on drug delivery using pHEMA hydrogels with exhaustive details of researches explored till date. ER -