TY - JOUR
A1 - Pant, Ishita
A1 - Chaturvedi, Sujata
A1 - Tripathi, Chandra
A1 - Singh, Gurbachan
T1 - Relevance and interrelationship of progesterone receptor, Ki67, and p53 in meningiomas: An immunohistochemical analysis in 273 cases
Y1 - 2019/4/1
JF - International Journal of Health & Allied Sciences
JO - Int J Health Allied Sci
SP - 116
EP - 122
VL - 8
IS - 2
UR - https://www.ijhas.in/article.asp?issn=2278-344X;year=2019;volume=8;issue=2;spage=116;epage=122;aulast=Pant
DO - 10.4103/ijhas.IJHAS_82_18
N2 -
BACKGROUND: Meningiomas are among the most common of central nervous system neoplasms. These are classified into meningiomas with low risk of recurrence and aggressive behavior (World Health Organization [WHO] Grade I) and meningiomas with greater likelihood of recurrence and aggressive behavior (WHO Grade II and Grade III) according to the WHO 2016 criteria. A host of markers are implicated in the genesis, progression, and recurrence of meningiomas. This study was undertaken with the aim to analyze the sociodemographic profile of various grades of meningiomas and to assess the relevance and correlation between progesterone receptor (PR), Ki67, and p53 among these.
MATERIALS AND METHODS: Retrospective analysis was performed for 273 cases of intracranial and intraspinal meningiomas. All intracranial and intraspinal meningiomas were graded according to the WHO 2016 criteria. Immunohistochemistry was performed using PR, Ki67, and p53 in 273 cases. Statistical analysis was performed.
RESULTS: According to the WHO 2016 grading system, 254 were Grade I (93.04%), 14 were Grade II (5.13%), and 5 were Grade III (1.83%) meningiomas. According to the histological type, among Grade I, 207 meningiomas were transitional (75.82%), 11 meningothelial (4.03%), 11 angiomatous (4.03%), 8 psammomatous (2.93%), 6 fibroblastic (2.19%), 5 microcystic (1.83%), 4 metaplastic (1.47%), and 2 secretory (0.73%). Among Grade II, there were 13 cases of atypical meningiomas (4.76%) and 1 case of clear-cell meningioma (0.37%). Among Grade III, 3 meningiomas were rhabdoid variant (1.09%) and 2 cases were anaplastic meningiomas (0.37%). In all the cases, correlation with PR, p53, and Ki67 was assessed.
CONCLUSION: Immunohistochemical evaluation of PR status, p53 expression, and Ki67 labeling index do add information to the routine histopathological evaluation of meningiomas. In addition, these markers do help in assessing the biological behavior of meningiomas.
ER -