REVIEW ARTICLE
Year : 2013 | Volume
: 2 | Issue : 2 | Page : 63--68
Novel solid self-emulsifying pellets: An approach for enhanced oral delivery of poorly soluble drug
Natarajan Jawahar, B Vivekananda Raju
Department of Pharmaceutics, JSS College of Pharmacy, Ootacamund, Tamil Nadu, India
Correspondence Address:
Natarajan Jawahar
Department of Pharmaceutics, JSS College of Pharmacy, Ootacamund - 643 001, Tamil Nadu
India
In recent years, it has been a great challenge for lipophilic drugs to get converted into an orally administered formulation with sufficient bioavailability. Over 40% of the new chemical entities are poorly soluble, which lead to decreased bioavailability, higher inter- and intra-subject variability, and lack of dose proportionality. Self-emulsifying drug delivery system has come to the fore for the enhancement of oral bioavailability. The prime characteristic - their ability to form fine oil-in-water (o/w) emulsion or micro-emulsions upon mild agitation following dilution by an aqueous phase - is quite promising. The present review discusses the feasibility of producing solid self-emulsifying pellets using the extrusion/spheronization technique and their development; it also focuses on related problems and possible future research directions.
How to cite this article:
Jawahar N, Raju B V. Novel solid self-emulsifying pellets: An approach for enhanced oral delivery of poorly soluble drug.Int J Health Allied Sci 2013;2:63-68
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How to cite this URL:
Jawahar N, Raju B V. Novel solid self-emulsifying pellets: An approach for enhanced oral delivery of poorly soluble drug. Int J Health Allied Sci [serial online] 2013 [cited 2023 Oct 1 ];2:63-68
Available from: https://www.ijhas.in/article.asp?issn=2278-344X;year=2013;volume=2;issue=2;spage=63;epage=68;aulast=Jawahar;type=0 |
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