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REVIEW ARTICLE
Year : 2013  |  Volume : 2  |  Issue : 2  |  Page : 63-68

Novel solid self-emulsifying pellets: An approach for enhanced oral delivery of poorly soluble drug


Department of Pharmaceutics, JSS College of Pharmacy, Ootacamund, Tamil Nadu, India

Correspondence Address:
Natarajan Jawahar
Department of Pharmaceutics, JSS College of Pharmacy, Ootacamund - 643 001, Tamil Nadu
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2278-344X.115678

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In recent years, it has been a great challenge for lipophilic drugs to get converted into an orally administered formulation with sufficient bioavailability. Over 40% of the new chemical entities are poorly soluble, which lead to decreased bioavailability, higher inter- and intra-subject variability, and lack of dose proportionality. Self-emulsifying drug delivery system has come to the fore for the enhancement of oral bioavailability. The prime characteristic - their ability to form fine oil-in-water (o/w) emulsion or micro-emulsions upon mild agitation following dilution by an aqueous phase - is quite promising. The present review discusses the feasibility of producing solid self-emulsifying pellets using the extrusion/spheronization technique and their development; it also focuses on related problems and possible future research directions.


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